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Activelle (1+0.5) Mg
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What is Activella Tablet
Activella Tablet is a GMP-compliant medicine that contains Estradiol and Norethindrone as active salts. It is an Estrogen/Progestin-HRT (Hormone Replacement Therapy) drug that reduces the risk of bone loss and treats symptoms of Menopause, like night sweats or vaginal dryness. Novo Nordisk Health Care AG manufactures Activella.
Estradiol acts as an Estrogen replacement, and Norethindrone, a synthetic Progestin, mimics the action of Progesterone. Estradiol increases Estrogen levels to relieve menopausal symptoms and maintain bone density. Norethindrone binds to the receptors of Progesterone to mimic its activity and decrease the risk of Endometrial Hyperplasia (significant thickening of the uterus lining).
For the prevention of Osteoporosis, hot flashes, and vaginal issues, the general recommended dosage is one tablet a day on a daily basis, with each tablet containing 0.5 mg Norethindrone and 1 mg of Estradiol. The strength may vary depending on the severity of the condition.
Store the tablets at 20°C and 25°C (room temperature). Ensure the storage place is dry, cool, and protected from light. Some temporary side effects include hair loss, headache, troubled sleep, or bloating.
Activella Tablet may interact with inhibitors and/or inducers of CYP3A4 (liver and kidney enzyme that participates in the breakdown of medications), which, in turn, can adversely impact the drug metabolism. It may also interact with medicines for fungal infections, Rifadin (medication for Tuberculosis), or medications for AIDS/HIV.
What are the benefits of taking Activella Tablet
Activella Tablet is a combination of Estradiol and Norethindrone, which mimics two key hormones of women's anatomy: Estrogen and Progesterone.
- Prevents menopausal symptoms: During Menopause, Estradiol increases the declining Estrogen levels to stabilize the control of the hypothalamus (a part of brain) over the body temperature, preventing vasomotor symptoms like night sweats and hot flashes. It also enhances vaginal tissue health by improving blood flow and elasticity.
- Treatment of Postmenopausal Osteoporosis: Reduced Estrogen levels after Menopause give rise to poor bone density and significant bone breakdown, which is called Osteoporosis. Estradiol has the key role in blocking the cells (osteoclasts) that trigger bone breakdown to lower bone resorption. It also promotes the survival of bone-building cells (osteoblasts).
- Being a synthetic Progestin, Norethindrone protects the uterus from Cancer or Endometrial Hyperplasia (abnormal thickening of the uterus lining).
How to take Activella Tablet
Since Activella is a hormone therapy combining two hormones, it is a prescription-only medication. The doctor may adjust the dosage.
Here are the general dosage guidelines:
- Take one tablet daily as a whole.
- Avoid stopping the tablet intake in the middle of a pack.
- Start the new pack when the previous one is finished.
Postmenopausal women should be regularly monitored to determine if treatment is still required and when the medication should be discontinued.
Strengths and Substitutes
Substitutes of Estradiol are available at Cheap Medicine Shop, including:
| $8.00/10 tablets | |
| $2.70/10 tablets |
What are the side effects of Activella Tablet
Some of the most common side effects, with incidence rate around 5%, include:
- Nausea
- Headache
- Back ache
- Insomnia
- Weight gain
- Thickening of the endometrium (uterus lining)
Consult a doctor or discontinue the medication if you experience vision loss or severe hypercalcemia (excessive calcium in the blood).
Safety Advise
Liver disease
Individuals with liver conditions should avoid this medication as there is a risk of dysfunctional drug processing which will lead to accumulation of medication in the body and may damage liver further. Consult a healthcare professional first.
Kidney impairment
Activella may cause fluid retention, so it is advised that patients with kidney disease take the medication only under clinical observation.
Pregnant and breastfeeding women
Pregnant women are advised against using Activella Tablets due to potential risks to fetal development. Norethindrone and Estradiol may pass into breastmilk and affect the nursing baby. So, consult a doctor before use.
Avoid
Avoid grapefruit juice as it can increase the risk for side effects by increasing the Activella level in your blood. Since the impact of alcohol on Norethindrone and Estradiol is unclear, consult your doctor before drinking.
FAQs
Who should not take Activella?
Women with vaginal bleeding, allergy of Norethindrone and Estradiol, and history of blood clots should avoid Activella. Also, in case of Diabetes, obesity, and pregnancy, this medication should be avoided.
How much Estrogen is in Activella?
One tablet of Activella contains 1 mg of Estradiol, an estrogen replacement. The tablet with an Estradiol strength of 0.5 mg is also available. Dosage varies from person to person.
Does Activella cause weight gain?
Yes, Activella can cause weight gain in some individuals, mainly due to fluid retention. However, it is debatable whether this weight change is triggered by aging and Menopause or directly by the medication.
Do you get a period on Activella?
Yes. Some women may experience spotting or irregular bleeding during the first few months of Activella treatment. However, this usually decreases over time. Research shows that after 12 months of use, about 86% of women no longer have periods (a condition known as amenorrhea).
How long before Activella starts working?
Activella generally produces its therapeutic effects within a few days after taking the tablet. Still, it can take 3 to 4 weeks, or longer in some cases, to produce its complete benefits.
What is the most common side effect of Estradiol?
The most common side effects of Estradiol are hair loss, headache, nausea, breast pain, and bloating. These side effects are usually temporary and subsides as your body adjusts to this hormonal therapy. Seek a doctor when any of these effects become severe.
Does Estradiol raise cholesterol?
No, Estradiol doesn't raise cholesterol. It is known to have a positive impact on cholesterol levels by increasing good cholesterol (High-Density Lipoprotein or HDL) and decreasing bad cholesterol (Low-Density Lipoprotein or LDL).