Minirin Nasal Spray 2.5 ml
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CMS2648
What is Minirin Nasal Spray
Minirin Nasal Spray is a synthetic antidiuretic hormone medication used to treat central diabetes insipidus, nocturnal enuresis (bedwetting), and certain bleeding disorders. Its active ingredient is Desmopressin acetate, which is a synthetic analog of vasopressin, the natural human antidiuretic hormone.
Ferring Pharmaceuticals is the leading manufacturer of Minirin Nasal Spray, available in a 2.5 ml bottle that delivers approximately 25 metered doses. Each spray contains 10 mcg of Desmopressin acetate.
Side effects may include nasal congestion, Rhinitis, headache, and in rare cases, Hyponatremia (low blood sodium). The medication should be used cautiously in patients with conditions that might be aggravated by fluid retention.
Store the spray upright at room temperature, protected from light, and keep refrigerated before opening. Once opened, use within 6 weeks. Avoid freezing the solution and keep it out of reach of children.
What are the benefits of Minirin Nasal Spray
Minirin Nasal Spray contains Desmopressin, which mimics the action of antidiuretic hormone (ADH) by increasing water reabsorption in the kidneys. This reduces urine volume and increases urine concentration, helping control fluid balance in the body.
The benefits of Minirin spray include:
- Effective management of central diabetes insipidus symptoms
- Control of excessive urination and accompanying thirst
- Treatment of nocturnal enuresis (bedwetting) in children over 5 years
- Management of certain bleeding disorders by increasing blood clotting factors
- Temporary control of polyuria and polydipsia following pituitary surgery
It is crucial to note that fluid intake should be carefully regulated while using this medication to prevent water intoxication and Hyponatremia.
How to take Minirin Nasal Spray
Minirin Nasal Spray is a prescription medication that should be taken as per your doctor's instructions. Here are the general guidelines:
- Adults typically require 1-2 sprays in each nostril daily, divided into morning and evening doses. The doctor determines dosage and timing for children based on weight and condition.
- Prime the pump before first use by pressing 4 times.
- Clear nasal passages before administration. Insert the spray nozzle into the nostril and press firmly to deliver one spray.
- Do not exceed the prescribed dosage.
Strengths and substitutes
The strengths and substitutes available for Minirin spray are:
| $26.74 |
What are the side effects of Minirin Nasal Spray
Minirin Nasal Spray is generally well-tolerated when used as directed. However, it may cause side effects, including:
- Nasal congestion or irritation
- Headache
- Nausea
- Water intoxication (Hyponatremia) with symptoms like headache, confusion, and seizures
These adverse effects generally do not require medical consultation unless severe or persistent. However, symptoms of Hyponatremia require immediate medical attention.
Safety Advice
Liver disease
People with mild to moderate liver impairment should use Minirin with caution, as the metabolism of Desmopressin may be affected. Dose reduction may be necessary, and liver function should be monitored regularly. Avoid use in severe liver disease unless the benefits outweigh the risks. Consult a doctor for safety.
Kidney impairment
Minirin spray should be used cautiously in patients with moderate to severe kidney impairment (creatinine clearance below 50 mL/min). These patients are at increased risk of water retention and Hyponatremia. Regular monitoring of serum sodium levels and kidney function is essential. Consult a doctor for safety.
Pregnant and breastfeeding women
Limited data exist on Minirin use during pregnancy, but animal studies show no harmful effects. It should be used only if needed, and the potential benefits outweigh the risks. Desmopressin passes into breast milk in small amounts, but effects on breastfed infants are unlikely at therapeutic doses. Consult your doctor before use.
Avoid
Avoid excessive fluid intake while using Minirin spray to prevent water retention and low sodium levels. Also, avoid alcohol and medications like NSAIDs, SSRIs, and tricyclic antidepressants that can increase the medication’s effects. Do not use nasal decongestants that may interfere with absorption, and avoid activities requiring mental alertness if you feel dizzy.
FAQs
How quickly does Minirin Nasal Spray work?
Minirin spray begins working within 15-30 minutes after administration. The antidiuretic effect peaks at 1-5 hours and lasts 8-12 hours. However, results can vary depending on the individual response and dosage.
Can I use Minirin Nasal Spray if I have a common cold?
Avoid using Minirin spray during nasal congestion or infection, as absorption may be inconsistent. Consult your doctor about temporary dosage adjustments or alternative formulations during illness.
What should I do if I miss a dose?
If you remember, take the missed dose of Minirin spray within 1-2 hours of the scheduled time. If it's almost time for your next dose, leave the missed one and resume with your regular schedule. Never take a double dose.
Can children use Minirin Nasal Spray?
Yes, children can use Minirin spray for approved indications like central diabetes insipidus and nocturnal enuresis (typically over age 5). However, a physician must carefully determine dosing based on the child's weight and response.
How should I store Minirin Nasal Spray?
Store unopened Minirin Nasal Spray in the refrigerator (2-8°C). After opening, it can be stored at room temperature (below 25°C) for up to 6 weeks. Keep the bottle upright and protected from light.